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Trend kanker payudara di Semarang: Analisis tipe histologi dan molekuler
Abstract
Kanker payudara merupakan kanker dengan insidens tertinggi pada wanita di dunia maupun di Indonesia. Kanker payudara juga menduduki peringkat pertama sebagai penyebab kematian pada wanita akibat kanker di dunia dan di Indonesia. Tiap tahun ditemukan 1.200 kasus baru penderita kanker payudara pada usia dibawah 30 tahun, Status homonal melalui ekspresi estrogen receptors (ER) dan progesterone receptors (PR) telah lama digunakan untuk menentukan kesesuaian penderita terhadap terapi endokrin. Belakangan ini pemeriksaan human epidermal growth factor receptor-2 (HER-2/neu) telah digunakan sebagai petanda prognosis dan untuk memprediksi respon pengobatan. Untuk penderita dengan triple negative tumors ini perlu diadakan penelitian lebih lanjut untuk menemukan petanda prognosis dan target terapi baru.
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