Devy Octarina, M Kamaluddin, Theodorus -


Diabetes mellitus is a chronic metabolic disorder characterized by blood glucose levels greater than normal - hyperglycemia (fasting blood glucose ? 126 mg / dl or post prandial blood glucose ? 200 mg / dl or blood glucose ? 200 mg / dl) caused by insulin deficiency and or insulin resistance. One way to control blood glucose levels can be done in a traditional way using natural ingredients. Belimbing wuluh fruits (Averrhoa bilimbi Lin.) has been widely used by the community because containing many active substances, including flavonoids. Flavonoids found in Belimbing wuluh fruit are dihydromyricetin. The purpose of this study was to assess the effectivity of belimbing wuluh fruit ethanolic extract on decreasing 2-hour post prandial blood glucose of male rats compared to acarbose. This type of study is in vivo laboratory experimental (pre and posttest only). The research was done from July to September 2020 in the Biochemistry Laboratory, Biotechnology Laboratory and Animal House, Faculty of Medicine, Sriwijaya University, Palembang. The population of study were white male rats. Statistical data analysis used SPSS version 22. Based on the results of the study, it was concluded that the ethanolic extract of belimbing wuluh fruit (Averrhoa bilimbi Linn.) was effective on decreasing 2-hour post prandial blood glucose levels of diabetic male white rats.


Diabetes mellitus, blood glucose

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ADA. Classification and Diagnosis of Diabetes: Standards of Medical Care in diabetes. Diabetes Care. 2019;42(January):S13–28.

Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar 2018. Riskesdas [Internet]. 2018;1–100. Available from:

Kurian AJ, Geetha G, Thavamani BS. Isolation and Characterisation of an Isolated Flavonoid from Averrhoa bilimbi. Asian J Chem Sci. 2018;5(1):1–8.

Lawag IL, Aguinaldo AM, Naheed S, Mosihuzzaman M. ?-Glucosidase Inhibitory Activity of Selected Philippine Plants. J Ethnopharmacol [Internet]. 2012;144(1):217–9. Available from:

B.Kurup S, Mini S. Attenuation of Hyperglycemia and Oxidative Stress in Streptozotocininduced Diabetic Rats by Aqueous Extract of Averrhoa Bilimbi Linn Fruits. Int J Pharm Sci Res. 2014;5(11):4981–8.

Candra S. Pengaruh Pemberian Ekstrak Buah Belimbing Jurnal Media Medika Muda Pengaruh Pemberian Ekstrak Buah Belimbing. Media Med Muda. 2012;

Rahmawati RD, Kusumastuti AC. Pengaruh Pemberian Sari Buah Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Kadar Glukosa Darah Tikus Sprague Dawley. J Nutr Coll. 2015;4(4):486–91.

Chougale AD, Panaskar S, Arvindekar A. Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period. 2014;

Szkudelski T. The Mechanism of Alloxan and Streptozotocin Action in B cells of The Rat Pancreas. Physiol Res. 2001;50(6):537–46.

Susanti EY. Pengaruh Pemberian Sari Belimbing Wuluh (Averrhoa bilimbi. L) terhadap Kadar Glukosa Darah Puasa Wanita Dewasa. Vol. 5, Jnh (Journal of Nutrition and Health). 2017. 102–115 p.

Ganiswara, S., R. Setiabudi, U. Sjamsuddin Z. B. Farmakologi dan Terapi. Edisi IV, Farmakologi FK UI : Jakarta. Bagian Farmakol Fak Kedokt Univ Indones. 2016;

Bacharach AL, Laurence DR. Preface. In: Evaluation of Drug Activities. Elsevier; 1964. p. ix–xii.

Ou S, Kwok K, Li Y, Fu L. In Vitro Study of Possible Role of Dietary Fiber in Lowering Post Prandial Serum Glucose. J Agric Food Chem. 2011;49:1026–9.

Dikeman CL, Fahey GC. Viscosity as related to dietary fiber: A review. Crit Rev Food Sci Nutr. 2006;46(8):649–63.

Degeeter M, Williamson B. Alternative Agents in Type 1 Diabetes in Addition to Insulin Therapy. J Pharm Pract. 2016;29(2):144–59.

Al-Ishaq, Khalid R, Abotaleb M, Kubatka P, Kajo K, Büsselberg D. Flavonoids and Their Anti-Diabetic Effects : Cellular Mechanisms and Effects to Improve Blood Sugar Levels. 2019;



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