ANALYSIS OF LIVER FUNCTION DISORDERS IN CRUMB RUBBER FACTORY WORKERS IN PALEMBANG CITY, SOUTH SUMATRA

Ferly Oktriyedi, Irfannuddin Irfannuddin, Ngudiantoro Ngudiantoro, Muhammad Hatta Dahlan

Abstract


Workers are required to receive Occupational Safety and Health protection. Work accidents can be influenced by physical, chemical, biological, ergonomic and psychological factors. Natural rubber factory is one of the industries that have risks to these factors. This study used a cross-sectional design. Data analysis used the CHAID (Chi-Square Automatic Interaction) method. P value < 0.05 was considered statistically significant. The results of the study showed that the average concentration of H2S in the air and in solids was above the quality standard and the average concentration of H2S in water was still below the quality standard. The average concentration of NH3 in water and in solids is above the quality standard and the average concentration of NH3 in the air is still below the quality standard. The results of the CHAID method analysis showed that glucose levels were associated with impaired liver function (p = 0.000; chi square = 48.766) and the risk of H2S exposure in the air with impaired liver function (p = 0.007; chi square = 7.944). In addition, 3 segments of liver function disorders were also found, namely Segment 1: Workers with abnormal BBS levels, high air exposure H2S; segment 2: Workers with abnormal glucose levels, low air exposure H2S; segment 3: Workers with normal glucose levels. Based on this segment, it was also found that the percentage of risk of experiencing liver function disorders were workers in segment 2 (36.3%) and segment 1 (17.4%).

Keywords


natural rubber, industry, occupational diseases, impaired liver function

Full Text:

PDF

References


PP RI No.88. Peraturan Pemerintah Republik Indonesia Nomor 88 Tahun 2019 Tentang Kesehatan Kerja. Pemerintah RI. 2019;24.

ILO. Meningkatkan Keselamatan dan Kesehatan Pekerja Muda. Kantor Perburuhan Internasional , CH- 1211 Geneva 22, Switzerland. 2018. 50 p.

Morse T, Meyer JD, St. Louis T, Storey E. Occupational Disease in Connecticut: 2021. Conn Med. 2021;1–46.

Kementerian Ketenagakerjaan RI. Kliping Berita Ketenagakerjaan 13 Januari 2021. http://perpustakaan.kemnaker.go.id/admin/assets/product_img/pdf/13_Januari_2020.pdf. 2021;

Sasmita A, Reza M, Rodesia Mustika Rozi. Pemetaan Dan Perhitungan Pemaparan Tingkat Kebisingan Pada Industri Pengolahan Kayu Di Kecamatan Siak, Provinsi Riau. Al-Ard J Tek Lingkung. 2021;6(2):68–76.

Oktriyedi F, Dahlan MH, Irfannuddin, Ngudiantoro. Impact of latex coagulant various from rubber industry in South Sumatera. AIP Conf Proc. 2021;2344(April).

Gapkindo. Members of Gapkindo, South Sumatra Branch [Internet]. 2020 [cited 2020 Jan 10]. Available from: https://www.gapkindo.org/cabang/92-south-sumatera

Oktriyedi F, Irfannuddin, Ngudiantoro, Dahlan MH, Nurhayati. Characteristics of Polluters In The Working Environment of PT X Palembang City. Pollut Res. 2021;40(2):438–43.

Hine C, Zhu Y, Hollenberg AN, Mitchell JR. Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. Antioxidants Redox Signal. 2018;28(16):1483–502.

Oktriyedi F, Irfannuddin, Ngudiantoro, Dahlan MH. Polluting Factors in Rubber Plants that Interfere with Health. Maj Kedokt Sriwij. 2021;53(2 April):42–8.

Edwin T, Regia RA, Irfan M, Kurniawan Y. Analisis Resiko Pada Bagian Produksi Pabrik Pengolah Getah Karet Menggunakan Metode HIRARC (Studi Kasus PT X Kota Padang). J Sains dan Teknol. 2019;18(1):21.

Juwita P, Sugiman, Hendikawati P. Ketepatan Klasifikasi Metode Regresi Logistik dan Metode Chaid dengan Pembobotan Sampel. Indones J Math Nat Sci. 2021;44(1):22–33.

Ministry of Manpower and Transmigration. Permenakertrans No. Per.13 / MEN / X 2011 concerning Threshold Value of Physical and Chemical Factors in the Workplace. 2011. p. 1–54.

State Minister for the Environment. Decree of the State Minister for the Environment No. 50 of 1996 concerning: Odor Level Standards. 1996. p. 1–5.

Governor of South Sumatra. South Sumatra Governor Regulation No. 8 of 2012 concerning: Liquid Waste Quality Standards for Industrial Activities, Hotels, Hospitals, Domestic and Coal Mining. 2012. p. 1–50.

State Minister for the Environment. Regulation of the Minister of Environment of the Republic of Indonesia No. 5 of 2014 concerning Wastewater Quality Standards. Kementrian Lingkungan Hidup dan Kehutanan. 2014. p. 1–83.

García-Compeán D, González-González JA, Lavalle-González FJ, González-Moreno EI, Maldonado-Garza HJ, Villarreal-Pérez JZ. The treatment of diabetes mellitus of patients with chronic liver disease. Ann Hepatol [Internet]. 2015;14(6):780–8. Available from: http://dx.doi.org/10.5604/16652681.1171746

Bai XP, Fan YM, Zhang L, Yang GH, Li X. Influence of Liver Cirrhosis on Blood Glucose, Insulin Sensitivity and Islet Function in Mice. Am J Med Sci [Internet]. 2021;362(4):403–17. Available from: https://doi.org/10.1016/j.amjms.2021.07.005

Garcia-Compean D, Jacquez-Quintana JO, Gonzalez-Gonzalez JA, Maldonado-Garza H. Liver cirrhosis and diabetes: Risk factors, pathophysiology, clinical implications and management. World J Gastroenterol. 2009;15(3):280–8.

Azeez FS, Saadi AM. Evaluation of liver function in type 2 diabetic patients during clinical trials in Kirkuk City. Res J Pharm Technol. 2019;12(4):1659–63.

Almahmoud MH, Al Khawaja NM, Alkinani A, Khader Y, Ajlouni KM. Prevalence of fatty liver disease and its associated factors among Jordanian patients with type 2 diabetes mellitus: A cross-sectional study. Ann Med Surg [Internet]. 2021;68(July):102677. Available from: https://doi.org/10.1016/j.amsu.2021.102677

Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW. Non-alcoholic fatty liver disease and diabetes. Metabolism [Internet]. 2016;65(8):1096–108. Available from: http://dx.doi.org/10.1016/j.metabol.2016.01.001

Acharya A, Wudneh E, Krishnan R, Ashraf A, Tohid H. Diabetes and Liver an Association: Hepatogenous Diabetes Mechanism and Some Evidences. J Cell Sci Ther. 2016;07(06).

Wu DD, Wang DY, Li HM, Guo JC, Duan SF, Ji XY. Hydrogen sulfide as a novel regulatory factor in liver health and disease. Oxid Med Cell Longev. 2019;2019.

Cao X, Ding L, Xie ZZ, Yang Y, Whiteman M, Moore PK, et al. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? Antioxidants Redox Signal. 2019;31(1):1–38.

Yang B, Bai Y, Yin C, Qian H, Xing G, Wang S, et al. Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes. Arch Toxicol [Internet]. 2018;92(6):2093–108. Available from: http://dx.doi.org/10.1007/s00204-018-2208-x

Jin X, Chen D, Wu F, Zhang L, Huang Y, Lin Z, et al. Hydrogen Sulfide Protects Against Ammonia-Induced Neurotoxicity Through Activation of Nrf2/ARE Signaling in Astrocytic Model of Hepatic Encephalopathy. Front Cell Neurosci. 2020;14(October):1–13.

Yuan D, Huang Y, Fu Y, Xie J, Huang Y, Zhou S, et al. Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure. Exp Ther Med. 2020;20(1):671–7.




DOI: https://doi.org/10.32539/mks.v54i2.17842

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

Indexed in:

        .                 

 


Editorial Office

Fakultas Kedokteran Universitas Sriwijaya
Jl. Dr. Moehammad Ali Kompleks RSMH Palembang 30126, Indonesia

Telp. 0711-316671, Fax.: 0711-316671

Email:mksfkunsri@gmail.com 

 
Flag Counter
Web Analytics View My Stats