Effects of Ciplukan Fruit Extract (Physallis peruvenia) on T4 levels in White Rats

Nita Parisa

Abstract


Hyperthyroidism is a condition where there is an increase in thyroid hormone synthesis and secretion so that the level of thyroid hormone in the blood increases. In 2013, data showed 0.4% of Indonesia's population experienced hyperthyroidism. Ciplukan fruit (Physalis peruviana) is an Indonesian herb that is thought to have an effect on thyroid hormone. This research is an in vivo experimental study. The research subjects were 30 Wistar strain white rats divided into 5 groups: negative control (distilled water), positive control (PTU 100 mg / kgBW), groups 3, 4, and 5 Ciplukan fruit extracts at a dose of 250 mg/kgBW, 500 mg/kgBW, and 1000 mg/kgBW. The results of the examination showed a decrease in T4 levels in the treatment with positive control and administration of ciplukan fruit extracts. There was a difference in the reduction in T4 levels for the group giving ciplukan extract doses of 1, 2, and 3 (p <0.05). It can be concluded that Ciplukan fruit extract with a dose of 250 mg/kgBW, 500 mg/kgBW, and 1000 mg/kgBW has potential as an anti-hyperthyroidism.


Keywords


ciplukan, hyperthyroidism, thyroid, T4, PTU

Full Text:

PDF

References


The Indonesian Society of Endoc-rinology. Indonesian Clinical Practice Guidelines for Hyperthyroidism. Journal of the ASEAN Federation of Endocrine Societies; 2012; 27(1):34–39.

Available from

https://asean-endocrinejournal.org/index.php/JAFES/article/view/10/403.

Leo SD, Lee SY, and Braverman LE. Hyperthyroidism. Lancet; 2016 August 27; 388(10047): 906–918. doi:10.1016/ S0140-6736(16)00278-6.

Available from

http://www.ncbi.nlm.nih.gov/pubmed/27038492.

Peter N. Taylor, Diana Albrecht, Anna Scholz, Gala Gutierrez-Buey, John H. Lazarus, Colin M. Dayan, Onyebuchi E. Okosieme. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018 Mar 23 Published online 2018 Mar 23. doi: 10.1038/nrendo.2018.18.

Available from

http://www.ncbi.nlm.nih.gov/pubmed/29569622.

Topliss DJ and Eastman CJ. 5: Diagnosis and management of hyperthyroidism and hypothyroidism. MJA Practice Essentials; 2004; 180:186-193.

Available from

https://www.ncbi.nlm.nih.gov/pubmed/14960142.

Pusat Data dan Informasi (Pusdatin) Kementerian Kesehatan RI. Situasi dan Analisis Penyakit Tiroid. 2015; 1-7. Available from

https://www.depkes. go.id › download › infodatin-tiroid.

Hidayat T, Susbiantonny A, dan Yunitawati D. Pengaruh Ekstrak Etanol Ciplukan Terhadap Penurunan Kadar Thyroid Stimulating Hormone (TSH) Tikus Jantan Galur Wistar Induksi Propylthiouracil. MGMI; 2015; 7(1):1-10.

Available from

http://ejournal.litbang.depkes.go.id/index.php/mgmi/article/view/6060/4687

Saleh MI dan Hidayat R. Panduan Penggunaan Hewan Coba & Model Hewan Coba dalam Penelitian Kedokteran dan Kesehatan. Noer Fikri; 2017.

Vessal M, Rasti M, and Kooshes F. Modulation of the pituitary and basomedial hypothalamic lysyl-amino-peptidase activities by ?-estradiol and/or an aqueous extract of Physalis Alkekengi fruits. Comparative Bio-chemistry and Physiology Part B: Biochemistry and Molecular Biology; Volume 115, Issue 2, October 1996, Pages 267-271. https://doi.org/10.1016 /0305-0491(96)00078-8

Available from

https://www.sciencedirect.com/science/article/pii/0305049196000788

Foroosh SS, Ashtiyani SC, Akbarpour B, Attari MM, Zarei A, and Ramazani M. The Effect of Alcoholic Extract of Physalis alkekengi on Serum Concentration of Thyroid Hormones in Rats. Zahedan Journal of Research in Medical Sciences; 2012; 14(5): 7-11.

Available from

https://pdfs.semanticscholar.org/3489/ed1890ca3aa0296bb289c781e78ae607a2af.pdf

Wu S, Ng L, Lin D, Huang S, Wang S, and Lin C. Physalis peruviana extract induces apoptosis in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway. Cancer Lett 2004; 215: 199-208.

Juwita DA, Suhatri, & Hestia R. Evaluasi Penggunaan Obat Antitiroid Pada Pasien Hipertiroid di RSUP Dr. M. Djamil Padang, Indonesia. Jurnal Sains Farmasi & Klinis; 2018; 5(1): 49-54. Available from: http:// jsfk.ffarmasi.unand.ac.id › jsfk › article › download/




DOI: https://doi.org/10.32539/bji.v5i3.9872

Refbacks

  • There are currently no refbacks.


Editorial Office
Fakultas Kedokteran Universitas Sriwijaya
OJS: http:ejournal.unsri.ac.id/index.php/bji
Email: biomedicaljournalindonesia@gmail.com
CP: dr.Rachmat Hidayat, M.Sc(088225053819)

Creative Commons License
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya by https://ejournal.unsri.ac.id/index.php/bji is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.