EFEK TERATOGENIK EKSTRAK CIPLUKAN (PHYSALIS MINIMA LINN.) TERHADAP FETUS MENCIT (MUS MUSCULUS) GALUR SUB SWISS WEBSTER

Abstract

Abstract: A study concerning the teratogenic effect of Physalis minima Linn. on fetal mice (Mus musculus). Experiment with completely randomized design consisting 4 treatments and 5 replayments was applied. The treatments consisted control, P1 dose (1,4 mg/0,1 ml Tween 20/10 g weight), P2 dose (2,8 mg/0,1 ml Tween 20/10 g weight), and P3 dose (5,6 mg/0,1 ml Tween 20/10 g weight). Physalis minima Linn.extract solution was given by gevage on gestation day at the 9th until 17th. Day 18th treatment, the mice were weighed, was kelled by neck dislocation, and then preparations fetal skeleton was made. Data were analiyzed by Anova and Duncen test. Extract of Physalis minima Linn. lead to decrease fetal weight and delayed supraocciptal, cervical vertebrae bodies, sakrokaudal vertebrae arches, sternebrae, and posterior intermediet phalanges ossification. It can be concluded that Physalis minima Linn. extract have teratogenic effect on mice fetal.

Key words : mice fetal, Physalis minima Linn., teratogenic effect