Hubungan antara Tingkat Keparahan Obstructive Sleep Apnea dan Fungsi Kognitif pada Pasien Rumah Sakit Angkatan Laut Dr. Mintohardjo

Eko Satrio Bahari; Nurfitri - Bustamam; Maria Selvester Thadeus

doi:10.32539/V8I1.11073

Hubungan antara Tingkat Keparahan Obstructive Sleep Apnea dan Fungsi Kognitif pada Pasien Rumah Sakit Angkatan Laut Dr. Mintohardjo

Eko Satrio Bahari, Nurfitri - Bustamam, Maria Selvester Thadeus

Abstract

Hubungan antara Tingkat Keparahan Obstructive Sleep Apnea dan Fungsi Kognitif pada Pasien Rumah Sakit Angkatan Laut Dr. Mintohardjo. Prevalensi obstructive sleep apnea (OSA) pada populasi dewasa diperkirakan berkisar antara 5-14%. Sebagian besar pasien OSA di Rumah Sakit Angkatan Laut (Rumkital) Dr. Mintohardjo, Jakarta diukur tingkat keparahannya menggunakan polisomnografi. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat keparahan OSA dan fungsi kognitif. Penelitian menggunakan desain cross sectional dan teknik consecutive sampling. Data diambil dari 60 pasien OSA Rumkital Dr. Mintoharjo pada bulan April-Mei 2018. Data tingkat keparahan OSA diambil dari rekam medis, sedangkan data fungsi kognitif diukur menggunakan kuesioner Montreal Cognitive Assessment Indonesia version (MoCA-Ina). Subjek penelitian sebagian besar adalah pasien OSA laki-laki dengan usia rata-rata 43 tahun, berpendidikan tinggi, dan bekerja sebagai pegawai swasta. Berdasarkan data apnea-hypopnea index didapatkan 25 pasien OSA berat, 23 pasien OSA sedang, dan 12 pasien OSA ringan. Pada penelitian didapatkan pula sebanyak 45 pasien dengan fungsi kognitif terganggu dan 15 pasien dengan fungsi kognitif normal. Hasil uji Chi-square menunjukkan hubungan antara tingkat keparahan OSA dan fungsi kognitif (p = 0,000). Perlu diberikan edukasi kepada pasien OSA agar patuh mengikuti tatalaksana yang dianjurkan dokter, sehingga penurunan fungsi kognitif lebih lanjut dapat dicegah.

Keywords

fungsi kognitif; obstructive sleep apnea; polisomnografi

Full Text:

PDF

References

Mannarino MR, Di Filippo F, Pirro M. Obstructive sleep apnea syndrome. Eur J Intern Med. 2012;23:586-93.

Stansbury RC, Strollo PJ. Clinical manifestations of sleep apnea. J Thorac Dis. 2015;7(9):E298-310.

Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013;177:1006-14.

Gunawan PY, Haris S, Octaviana F. Prevalensi obstructive sleep apnea dengan kuesioner stop-bang dan risiko stroke pada populasi normal. Neurona. 2014;30(4):249-57.

Susanto AD, Yunus F, Antariksa B, Fitriani F, Luthfi A, Harlivasari AD. Prevalensi obstructive sleep apnea berdasarkan Kuesioner Berlin pada polisi lalu lintas di Jakarta Timur. J Respir Indo. 2016;36:67-72.

Thropy MJ, Broughton RJ, Cohn MA, Czeisler CA, Dement WC, Ferber R, et al. Obstructive sleep apnea syndrome. In: International classification of sleep disorders, editors. Diagnostic and coding manual. Westchester: American Academy of Sleep Medicine; 2001, p.52-61.

Ferini-Strambi L., Baietto C, Di Gioia MR, Castaldi P, Castronovo C, Zucconi M, et al. Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Research Bulletin 2003;61:87-92.

Sforza E, Roche F. Sleep apnea syndrome and cognition. Frontiers 2012;3(87):1-7.

Wreksoatmodjo BR. Pengaruh aktivitas fisik terhadap fungsi kognitif lanjut usia di Jakarta. CDK-236. 2016;41(1):7-12.

Husein N, Lumempouw S, Ramli Y, Herqutanto. Uji Validitas dan realibilitas Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) untuk skirining gangguan fungsi kognitif. Neurona 2010;27(4):15-21.

Hollis AM, Duncanson H, Kapust LR, Xi PM, O’Connor MG. Validity of the Mini-Mental State Examination and the Montreal Cognitive Assessment in the prediction of driving test outcome. J Am Geriatr Soc. 2015;63:988-92.

Setyaningrum SD. 2016. Hubungan Fungsi kognitif dengan riwayat obstructive sleep apnea syndrome pada pasien pasca stroke iskemik di RSUP Dr Kariadi. [Skripsi]. Semarang: Fakultas Kedokteran Universitas Diponegoro.

Gabbay IE, Lavie P. Age- and gender-related characteristics of obstructive sleep apnea. Sleep Breath 2012;16:453-60.

Lindberg E. Epidemiology of OSA. Eur Respir Mon. 2010;50:51-68.

Wimms A, Woehrle H, Ketheeswaran S, Ramanan D, Armitstead J. Obstructive sleep apnea in women: specific issues and interventions. BioMed Research International 2016:1-9.

Lavie P, Lavie L, Herer P. All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age. Eur Respir J. 2005;25:514-20.

Yusop CYC, Mohamad I, Mohammad WMZW, Abdullah B. Cognitive function among obstructive sleep apnea patients in North East Malaysia. J Natl Med Assoc. 2017;109:215-20.

Kim SJ, Lee JH , Lee DY, Jhoo JH, Woo JI. Neurocognitive dysfunction associated with sleep quality and sleep apnea in patients with mild cognitive impairment. Am J Geriatr Psychiatry 2011;19(4):374-81.

Starkov AA, Chinopoulos C, Fiskum G. Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium 2004;36:257-64.

Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011;183:1419-26.

Kerner NA, Roose SP. Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms. Am J Geriatr Psychiatry 2016;24:496-508.

Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. Journal Sleep Research 2002;11(6):1-16.

Lim DC, Pack AI. Obstructive sleep apnea and cognitive impairment: addressing the blood–brain barrier. Sleep Medicine Reviews. 2014;18(1):35-48.

Macey PM. Is brain injury in obstructive sleep apnea reversible? Sleep 2012;35(1):9-10.

Lee W, Swamy N, Kryger MH, Mokhlesi B. Epidemiology of obstructive sleep apnea: a population-based perspective. Expert Rev Respir Med. 2008;2(3):349-64.

Arli B, Bilen S, Titiz AP, Ulusoy EK, Mungan S, Gurkas E, et al. 2015. Comparison of cognitive functions between obstructive sleep apnea syndrome and simple snoring patients: OSAS may be a modifiable risk factor for cognitive decline. Applied Neuropsychology 2015;22:282–6.

DOI: https://doi.org/10.32539/V8I1.11073

Refbacks

There are currently no refbacks.

ISSN (Print) : 2406-7431
E-ISSN (Online) : 2614-0411

Editorial Office

Fakultas Kedokteran Universitas Sriwijaya
Jl. Dr. Moehammad Ali Kompleks RSMH Palembang 30126, Indonesia
Telp. 0711-352342, Fax.: 0711-373438
email: jurnalfkunsri@gmail.com

Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya by https://ejournal.unsri.ac.id/index.php/jkk is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Username
Password
Remember me